Poster abstracts of GCB 2015

نویسندگان

  • Martin Eisenacher
  • Jörg Rahnenführer
  • Axel Mosig
  • Sven Rahmann
چکیده

Autoimmune diseases arise from an abnormal immune response of the body against self-proteins leadingto tissue and organ damage. The excessive production of harmful autoantibodies (AAB) is a hallmarkof autoimmune diseases including Rheumatoid Arthritis (RA), Systemic Lupus Erythematodes (SLE),Systemic Sclerosis (SSc) and Sjögren’s Disease (SjS). Early diagnosis of autoimmune diseases is essentialfor initiation of therapy, but often challenging due to the heterogeneous clinical presentation of thediseases. Aim: AABs serve as diagnostic markers for various autoimmune diseases, but the co-occurrenceof AABs in SLE patients has rarely been analyzed. Detecting a broad set of AABs might help toinvestigate the number, co-prevalence and similarities of AAB reactivities in autoimmune diseases suchas SLE. Here, we describe the cluster analysis of a multiplexed AAB array of 87 AABs in a variety ofdisease entities.

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عنوان ژورنال:
  • PeerJ PrePrints

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015